Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses

   Aya Matsui, Cathy J. Spangler ... Eric Gouaux
2. 1. Structural Biology and Molecular Biophysics

   The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A

   Cristina Olivieri, Yingjie Wang ... Gianluigi Veglia

   The αC-β4 loop emerges as a hot spot for tuning allosteric cooperativity in the catalytic subunit of protein kinase A.
3. 1. Structural Biology and Molecular Biophysics

   Ais: streamlining segmentation of cryo-electron tomography datasets

   Mart G.F. Last, Leoni Abendstein ... Thomas H. Sharp
4. 1. Structural Biology and Molecular Biophysics

   Automated multiconformer model building for X-ray crystallography and cryo-EM

   Stephanie A Wankowicz, Ashraya Ravikumar ... James S Fraser

   Creating structural models with multiple conformations of proteins improves the fit of the model to experimental data X-ray crystallography and improve the model geometry.
5. 1. Structural Biology and Molecular Biophysics

   On the pH-dependence of α-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation

   Lukas Frey, Dhiman Ghosh ... Jason Greenwald
6. 1. Structural Biology and Molecular Biophysics

   The mechanism of mammalian proton-coupled peptide transporters

   Simon M Lichtinger, Joanne L Parker ... Philip C Biggin
7. 1. Structural Biology and Molecular Biophysics

   Structural features of heteromeric channels composed of CALHM2 and CALHM4 paralogs

   Katarzyna Drożdżyk, Martina Peter, Raimund Dutzler

   Structural studies revealing the organization of assemblies consisting of CALHM2 and CALHM4 subunits provide insight into the mechanism of heteromerization of large pore channels.
8. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   Structural analysis of the dynamic ribosome-translocon complex

   Aaron JO Lewis, Frank Zhong ... Ramanujan S Hegde

   A combination of cryo-electron microscopy, structure prediction, and evolutionary analyses reveal several functional states of the dynamic protein translocation machinery at the mammalian endoplasmic reticulum.
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase

   Roberto Efraín Díaz, Andrew K Ecker ... James S Fraser

   Biochemical and structural investigations of the pH adaptability of mouse Acidic Mammalian Chitinase offer insights for designing enhanced enzyme variants that can function in both lung and gut.
10. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Activity modulation in anaerobic ribonucleotide reductases: nucleotide binding to the ATP-cone allosterically mediates substrate binding to the active site

    Ornella Bimaï, Ipsita Banerjee ... Derek T. Logan