Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Haley R Noonan, Alexandra M Thornock ... Leonard I Zon
An in vivo reporter of TGFb signaling in zebrafish reveals that melanoma cells undergoing chronic TGFb signaling up-regulate extracellular matrix genes, down-regulate IFN, and are preferentially phagocytosed by macrophages compared to non-TGFb responsive melanoma cells.
Epithelial to mesenchymal transition (EMT) is a continuous process, in which the transition or intermediate states can be molecularly and spatially defined, shedding new light on development and disease EMT.
It is shown that the absence of the centrosome protein ninein provokes premature ossification during mouse development, due to a defect in the fusion of precursor cells into syncytial osteoclasts.
Comparative transcriptome analyses of human placenta reveal regulatory divergence between native highlanders and lowland immigrants living at high altitude, and a sex-biased pattern of genetic adaptation.
When used to capture fluid cognition, Brain Age likely fails to add substantially more information over and above chronological age and could miss up to around one-third of the variation.
Uninterrupted CAG repeat length determines onset age in Huntington's disease, and therefore, base editing strategies to generate CAA interruption offer new therapeutic opportunities as they diminish the disease-causing mutation.
Jonathan AC Menzies, André Maia Chagas ... Claudio R Alonso
A novel behavioural pipeline enables the quantitative analysis of the onset of movement in Drosophila embryos revealing that a microRNA modulates this process through regulatory effects in the sensory system.
Scaffolding protein RAPSYN can exert its NEDD8 E3 ligase activity to neddylate and stabilize oncogenic BCR-ABL by competing proteasomal degradation in Ph+ leukemia.
