9,638 results found
    1. Epidemiology and Global Health

    Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up

    Xia Li, Alexander Ploner ... Sara Hägg
    Biological ages have the potential to provide aging-related information beyond chronological age and can be predictive of mortality independently of both chronological age and different types of biological ages.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort

    Oliver Robinson, ChungHo E Lau ... Martine Vrijheid
    Among European children, shorter telomere length and older DNA methylation age relative to chronological age were associated with poorer behaviors, while older age, as predicted by a novel immunometabolic clock relative to chronological age, was associated with greater cognitive maturity.
    1. Epidemiology and Global Health

    Mortality: The challenges of estimating biological age

    Alexey Moskalev
    A comparison of nine different approaches over a period of 20 years reveals the most promising indicators for biological age.
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    1. Medicine
    2. Neuroscience

    Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer’s disease and neurodegeneration stratified by sex

    Irene Cumplido-Mayoral, Marina García-Prat ... OASIS study
    Brain-Age delta is a non-invasive marker of biological brain aging that is sensitive to the presence of risk factors and altered biomarkers of Alzheimer's disease in non-demented individuals.
    1. Chromosomes and Gene Expression

    A whole lifespan mouse multi-tissue DNA methylation clock

    Margarita V Meer, Dmitriy I Podolskiy ... Vadim N Gladyshev
    A robust mouse multi-tissue age predictor is presented that can be used to assess the DNA methylation age of mouse tissues and test the effects of longevity interventions.
    1. Epidemiology and Global Health

    The role of adolescent lifestyle habits in biological aging: A prospective twin study

    Anna Kankaanpää, Asko Tolvanen ... Elina Sillanpää
    Unhealthy lifestyle habits in adolescence associate with accelerated biological aging in young adulthood, but shared genetic factors underlying both lifestyle and biological aging may largely explain the observed associations.
    1. Developmental Biology
    2. Genetics and Genomics

    Epigenetic age-predictor for mice based on three CpG sites

    Yang Han, Monika Eipel ... Wolfgang Wagner
    Site-specific DNA methylation analysis at three CG dinucleotides by pyrosequencing provides a reliable measure for epigenetic aging of mice.
    1. Evolutionary Biology
    2. Genetics and Genomics

    High social status males experience accelerated epigenetic aging in wild baboons

    Jordan A Anderson, Rachel A Johnston ... Jenny Tung
    Among the factors that predict fitness in wild baboons, dominance rank in males, but not in females, is the best predictor of epigenetic aging.
    1. Cell Biology

    Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

    Wayne Mitchell, Ludger JE Goeminne ... Vadim N Gladyshev
    Partial chemical reprogramming is able to reduce the biological age of cells by diverting them to a different metabolic state marked by a strong upregulation of mitochondrial oxidative phosphorylation.
    1. Biochemistry and Chemical Biology

    A two-lane mechanism for selective biological ammonium transport

    Gordon Williamson, Giulia Tamburrino ... Arnaud Javelle
    A new cellular transport mechanism splits the substrate and separately translocates its fragments to achieve selectivity.

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