About
Established in Shanghai, China, L&L biopharma Co. LTD. is an innovative biologics R&D…
Activity
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All friends, After the ASCO Chicago 2024 and SAPA Boston 2024, I will have to travel to outside the US. It's a great pleasure to meeting you. If you…
All friends, After the ASCO Chicago 2024 and SAPA Boston 2024, I will have to travel to outside the US. It's a great pleasure to meeting you. If you…
Shared by Jiajian Liu
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Proudly presenting our Phase 1/1b, First-in-Human, multi-part study of DF6215, an engineered IL-2Rα-active agonist for advanced solid tumors, in the…
Proudly presenting our Phase 1/1b, First-in-Human, multi-part study of DF6215, an engineered IL-2Rα-active agonist for advanced solid tumors, in the…
Liked by Jiajian Liu
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Dear all, 2024 ASCO Chicago is ending. looking forward to seeing you all next year. in terms LB1410 and LB4330, here are home messages: LB1410:…
Dear all, 2024 ASCO Chicago is ending. looking forward to seeing you all next year. in terms LB1410 and LB4330, here are home messages: LB1410:…
Posted by Jiajian Liu
Experience
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L&L Biopharma, Co. LTD
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Education
Publications
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Aberrant production of IL-12 by macrophages from autoimmune-prone mouse strains is characterized by unique patterns of NF-kB expression and binding to the IL-12 p40 promoter
The Journal of Immunology, 2002. 169(1): 581-586.
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Borf-1 protein identified as a transcriptional trans-activator of bovine foamy virus. Science Bulletin, 1999, 44 (11): 1017-1021
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Distinct pathways for NF-kB regulation are associated with aberrant macrophage IL-12 production in Lupus- and diabetes-prone mouse strains.
The Journal of Immunology, 2003. 170: 4489-4496
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Functional Interaction between Peroxisome Proliferator-Activated Receptor {gamma} and {beta}-Catenin.
Molecular and Cellular Biology (MCB), 2006. 26(15): 5827-5837
See publicationscientific paper
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Peroxisome-proliferator-activated receptor gamma suppresses Wnt/beta-catenin signalling during adipogenesis. Biochem J. 2003 Dec 15; 376(Pt 3):607-13. doi: 10.1042/BJ20030426.
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Regulating the balance between PPAR gamma and beta-catenin signaling during adipogenesis. The Journal of Biological Chemistry (JBC), 2004. 279: 45020-45027
The Journal of Biological Chemistry (JBC), 2004. 279: 45020-45027
Patents
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ANTI-C-MET ANTIBODY AND ANTI-C-MET ANTIBODY-CYTOTOXIC DRUG CONJUGATE AND PHARMACEUTICAL USE THEREOF.
WO 2016165580 A1
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ANTI-SCLEROSTIN ANTIBODY, ANTIGEN BINDING FRAGMENT AND MEDICAL USE THEREOF
WO2016145961 A1
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ANTIBODY TARGETING CLDN18.2, BISPECIFIC ANTIBODY, ADC, AND CAR, AND APPLICATIONS THEREOF
WO2019242505A1
PCT, multiple products related to this patent either licensed out or on phase I/II clinical trials
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ANTIBODY TARGETING CLDN18.2, BISPECIFIC ANTIBODY, ADC, AND CAR, AND APPLICATIONS THEREOF
US2021230272A1
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ANTIBODY TARGETING CLDN18.2, BISPECIFIC ANTIBODY, ADC, AND CAR, AND APPLICATIONS THEREOF
US2021230272A1
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BISPECIFIC ANTIBODY AND USE THEREOF
US2021269521A1
total 65 patents, including PCT....
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BISPECIFIC ANTIBODY AND USE THEREOF
WO2020007240A1
PCT, multiple products related to this patent either out-licensed or on phase I/II clinical trials
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DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS INTO PANCREATIC ENDOCRINE2.
WO2013192005A2
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DIFFERENTIATION OF PLURIPOTENT STEM CELLS
WO2010002785A1/US20110091971
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DIFFERENTIATION OF PLURIPOTENT STEM CELLS
WO2010002846A1/US2010015711A1
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HUMAN INSULIN ANALOGUE AND ACYLATED DERIVATIVE THEREOF
KR20140104994A
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HUMAN INSULIN ANALOGUE AND ACYLATED DERIVATIVE THEREOF.
WO2013086927A1
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HUMAN RELAXIN ANALOGUE, PHARMACEUTICAL COMPOSITION OF SAME, AND PHARMACEUTICAL APPLICATION OF SAME
WO2015067113A1
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IL-17A CONJUGATE AND USES THEREOF.
WO2015070697A1
anti-IL17 product BLA in China, 2023, will in the market soon
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THROMBIN ANTIBODY, ANTIGEN-BINDING FRAGMENT AND PHARMACEUTICAL USE THEREOF
WO2017133673 A1
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TREATMENT OF PLURIPOTENT CELLS
WO2009132068A2
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Treatment of Pluripotent Cells
US20130337564 A1
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Treatment of Pluripotent Cells
US2009325293A1
More activity by Jiajian
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Tomorrow is World Veterinarian Day. Veterinarians are essential to the health of our pets, our food supply, our world. We honor the important work…
Tomorrow is World Veterinarian Day. Veterinarians are essential to the health of our pets, our food supply, our world. We honor the important work…
Liked by Jiajian Liu
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It was amazing to see some of those works of early scientists, and books authored in the years circa. 1500 and thereabouts. Was great to see what…
It was amazing to see some of those works of early scientists, and books authored in the years circa. 1500 and thereabouts. Was great to see what…
Liked by Jiajian Liu
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It was a busy day 1 of ASCO 2024. For all friends, collaborators missed talking on site, you are welcome to review our phase I data (below) for…
It was a busy day 1 of ASCO 2024. For all friends, collaborators missed talking on site, you are welcome to review our phase I data (below) for…
Shared by Jiajian Liu
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looking forward to talking with you for collaborations. L&L Biopharma, Co., LTD, Shanghai, China!
looking forward to talking with you for collaborations. L&L Biopharma, Co., LTD, Shanghai, China!
Shared by Jiajian Liu
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I’m happy to announce I’m starting a new position @Satellite as Chief Scientific Officer! I’m eager for the opportunity to apply my cell therapy…
I’m happy to announce I’m starting a new position @Satellite as Chief Scientific Officer! I’m eager for the opportunity to apply my cell therapy…
Liked by Jiajian Liu
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ASCO 2024 (May 31 - June 4, 2024) is coming. Following ASCO 2023, L&L Biopharma (上海健信生物）will update both LB1410, PD1(Keytruda)/Tim-3) bsAb and long…
ASCO 2024 (May 31 - June 4, 2024) is coming. Following ASCO 2023, L&L Biopharma (上海健信生物）will update both LB1410, PD1(Keytruda)/Tim-3) bsAb and long…
Posted by Jiajian Liu
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Today Satellite Bio will present new preclinical data at the American Society of Gene & Cell Therapy Annual Meeting demonstrating our ability to…
Today Satellite Bio will present new preclinical data at the American Society of Gene & Cell Therapy Annual Meeting demonstrating our ability to…
Liked by Jiajian Liu
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L&L Biopharma, Shanghai, China, is a biotech focusing on novel bi-,tri-specific antibody products for PD-1 resistant cancer patients. Currently, we…
L&L Biopharma, Shanghai, China, is a biotech focusing on novel bi-,tri-specific antibody products for PD-1 resistant cancer patients. Currently, we…
Posted by Jiajian Liu
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Exciting developments in the field of regenerative medicine are unfolding at an unprecedented pace! With nearly 8,000 stem cell clinical trials…
Exciting developments in the field of regenerative medicine are unfolding at an unprecedented pace! With nearly 8,000 stem cell clinical trials…
Liked by Jiajian Liu
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