Table 2 Summary of data used in the studies with pathologists

Dataset	Organ site	Categories assessed	No. of patches^a queried by SMILY	No. of patches^a queries by random search (negative control)	Scoring system (see Methods)
Organ-specific	Prostate	9 histologic features	270 by 2 pathologists	90 by 2 pathologists	0 or 100 for histologic feature match
Multi-organ	Prostate, breast, colon	10 histologic features	410 by 2 pathologists	145 by 2 pathologists	2 scores: 0 or 100 for histologic feature match, and 0 or 100 or “unclear” for organ match
Gleason grading	Prostate	Non-tumor and Gleason Patterns 3,4,5 (NT, GP3, GP4, GP5)	250 by 2 pathologists	90 by 2 pathologists	0 to 100 for tumor grade and histologic feature match

The database used for this study is identical to Table 1, while the query set was subsampled to retain a tractable number for manual evaluations
^aWhether search results were returned by SMILY versus random were randomized based on the ratios specified in this table and so the final numbers of patches are approximate

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