Table 4 Adjusted analysis for validation set C

From: Detection of signs of disease in external photographs of the eyes via deep learning

Prediction target

Number of visits

Odds ratio (95% CI), P value

Total

Positive (%)

Age (per decade)

Male

DLS (external eye image)

HbA1c ≥7%

8,995

5,119 (56.9%)

0.881

1.181

1.616

   

(0.841–0.923)

(0.958–1.456)

(1.541–1.695)

   

P < 0.001

P = 0.119

P < 0.001

HbA1c ≥8%

8,995

2,947 (32.8%)

0.830

1.185

1.706

   

(0.788–0.875)

(0.953–1.474)

(1.618–1.798)

   

P < 0.001

P = 0.126

P < 0.001

HbA1c ≥9%a

8,995

1,766 (19.6%)

0.807

1.004

1.770

   

(0.757–0.860)

(0.788–1.279)

(1.665–1.881)

   

P < 0.001

P = 0.973

P < 0.001

Tch ≥200 mg dl−1

9,304

1,935 (20.8%)

0.805

0.802

1.255

   

(0.755–0.860)

(0.646–0.997)

(1.174–1.341)

   

P < 0.001

P = 0.047

P < 0.001

Tch ≥240 mg dl−1

9,304

580 (6.2%)

0.768

0.813

1.272

   

(0.693–0.850)

(0.585–1.130)

(1.153–1.403)

   

P < 0.001

P = 0.217

P < 0.001

Tg ≥150 mg dl−1

9,280

3,825 (41.2%)

0.943

1.533

1.745

   

(0.902–0.985)

(1.227–1.914)

(1.668–1.825)

   

P = 0.009

P < 0.001

P < 0.001

Tg ≥200 mg dl−1

9,280

2,261 (24.4%)

0.908

1.870

1.759

   

(0.863–0.956)

(1.409–2.481)

(1.673–1.849)

   

P < 0.001

P < 0.001

P < 0.001

Tg ≥500 mg dl−1

9,280

205 (2.2%)

0.791

1.368

1.579

   

(0.678–0.922)

(0.630–2.973)

(1.419–1.757)

   

P = 0.003

P = 0.428

P < 0.001

Mild+ DR

9,518

992 (10.4%)

0.945

1.614

2.000

   

(0.881–1.013)

(1.078–2.417)

(1.892–2.114)

   

P = 0.112

P = 0.020

P < 0.001

Moderate+ DRa

9,518

454 (4.8%)

0.837

1.768

2.044

   

(0.756–0.925)

(0.968–3.229)

(1.913–2.184)

   

P < 0.001

P = 0.064

P < 0.001

Severe+ DR

9,518

203 (2.1%)

0.795

2.571

1.640

   

(0.689–0.917)

(0.937–7.057)

(1.525–1.763)

   

P = 0.002

P = 0.067

P < 0.001

DMEa

9,528

119 (1.2%)

0.590

2.135

1.746

   

(0.491–0.709)

(0.729–6.252)

(1.583–1.926)

   

P < 0.001

P = 0.167

P < 0.001

VTDRa

9,528

287 (3.0%)

0.725

2.043

1.962

   

(0.640–0.822)

(0.948–4.405)

(1.828–2.106)

   

P < 0.001

P = 0.068

P < 0.001

  1. aPre-specified primary prediction tasks. Bold font indicates P < 0.05.