The Lancet’s Post

- Top global metabolic risks in 2040: high BP, high BMI, high FBS (fasting plasma glucose). - Metabolic health aggregates risk factors to identify subphenotypes (e.g., metabolically unhealthy normal weight). - Since 2018, studies have used cluster analyses to propose new metabolic subphenotypes in high-risk patients. - Metabolic sub-phenotyping is not superior to established models for the general population. - Sub-phenotyping may improve risk prediction in specific subgroups (e.g., different BMI categories, diabetics). - Metabolic health concept is easier for physicians to apply and communicate. - Identifying risk clusters might help allocate individuals to risk groups, but its effectiveness for prevention and treatment is unclear. -Further studies in this regard need to be done https://lnkd.in/dN8HiCz5 #thelancet #metabolicriskfactors #metabolichealth #metabolicsubphenotyping

High blood pressure, high body mass index (BMI), and high fasting plasma glucose are projected to be among the top risk factors for years of life lost by 2040. This highlights the critical impact of metabolic health on overall life expectancy. Public health initiatives should focus on promoting interventions that address these metabolic risks. This could include raising awareness about healthy eating and the importance of regular physical activity, implementing policies to reduce the availability of unhealthy food options, and enhancing healthcare screening and intervention programs to manage these conditions effectively. Improving public awareness and understanding of how to maintain metabolic health could significantly reduce the burden of these risk factors on population health.

Cautionary tale for everyone to make sure at a very minimum these three health indicators are monitored and resolved as soon as possible: 1. high blood pressure 2. high BMI 3. high fasting plasma glucose If you have any of these three risk factors or are just obese, consider 2024 the year to make the change.

Risk factors for years of life lost including three metabolic risks: high blood pressure, BMI, and fasting plasma glucose introduced by #Lancet. All of these can be prevented by lifestyle modifications, however genetic and environmental factors can also play a role.

Physical exercise contributes significantly to the prevention and reduction of metabolic diseases.

One of the key factors that make weight loss extremely difficult can be a high insulin fasting level. Insulin, a hormone whose main function is to store energy, can contribute to metabolic dysfunction if not kept under control. Dr. Robert Lusting (M.D, M.S.L, professor in the department of endocrinology at the University of California) has repeatedly emphasized how important it is to always test the fasting insulin levels, as it can be one of the earliest markers of metabolic dysfunction. Insulin resistance can manifest in different organs such as the liver, ovaries, heart, and brain and cause different diseases such as NAFLD, PCOD, CVD, and Alzheimer's respectively. Although most labs consider an insulin level of less than 20 as normal, Lusting suggests that ideally, it's best to keep the levels as low as possible, preferably less than 10. Anything above 15, he says can be considered as insulin resistance. Glad that at NuGenomics we do include fasting insulin as one of the key test parameters to understand the metabolic health of clients. Shared in the snap below, is the amazing journey of reversing insulin resistance of a client who struggled with weight loss for the longest time and finally saw a budge in the scale once we started working on lowering her fasting insulin levels. All of it with good eating habits that emphasized no sugar and no refined grains and a regular exercise protocol that best suited their genetics. Not only did she lose the weight, 5 months down and she has managed to keep it off as well!

New Release: Endocrinology Target Series on Obesity The obesity epidemic is not just a health crisis but an economic one, costing the U.S. $261 billion in 2016. With over 40% of U.S. adults and more than 1 billion people globally battling obesity, the need for innovative research and improved long-term management is urgent. Our latest endocrinology target series provides a comprehensive look into obesity, offering: 🔹 Target Class Analysis 🔹 GWAS Target Insights 🔹 Targets in Animal Models 🔹 Emerging Targets Access the latest insights here: https://hubs.la/Q0281SZT0 #ObesityResearch #Endocrinology #BioTech #TargetIdentification

From healthy physiological processes to disease states, this curated collection on microbiome and metabolism in health and disease spans the latest research and reviews from across our portfolio - including Cell, Cell Metabolism, Cell Host & Microbe, and Trends in Endocrinology and Metabolism. https://hubs.li/Q0208GLp0