Serán BioScience’s Post

Day 3 of #AAPS #PharSci360! Check out Certara on today’s program: ◾ 10:30am – 11:30am | Certara Poster Abstract: Model Development and Verification of Mechanistic Long-Acting Suspension-Based Injectable Model | Author: Naresh Mittapelly, Ph.D, Don’t forget to stop by our booth #2615! We are continuing to conduct live demos as we introduce Simcyp™ Biopharmaceutics —a cutting-edge solution for model-informed formulation development (MIFD). This innovation, born from over four years of rigorous R&D and Biopharmaceutics applications by MIFD Experts, is designed to be your affordable modular solution. 

Are you facing #bioavailability challenges? Early formulation experts present 5 case studies where they explain how they successfully addressed bioavailability issues, discussing the different formulation approaches used. Stream the webinar on demand from the Evotec Science Pool here - https://hubs.ly/Q0280S-V0 and contact us to discuss your challenges with our experts. #bioavailability #drugdevelopment #researchneverstops

Serán BioScience's comprehensive formulation selection tool helps guide you to the most effective and attainable formulation technology. Our PPS and risk-assessment based approach balances selection of the drug product intermediate technology with the highest possible exposure with other considerations such as stability, pill burden, material availability, timelines and patient experience. Learn how our comprehensive formulation strategy focused on your unique program and corporate requirements can make certain your product has the best chance for success. #formulationdevelopment #drugdevelopment #cdmo

In Part One of Serán BioScience's two-part video series, Dr. Wesley Tatum covers key considerations for ASD product development. Formulation development of ASDs focuses on polymer selection, the ratio of drug to polymer, and the design of the ASD particles to develop a system that is physically stable while also demonstrating optimal performance. In this presentation, Dr. Tatum will cover some of the philosophies and principles used to guide ASD product formulation. Learn more and watch on-demand here: https://hubs.li/Q02vsfcK0 #amorphousdispersion #ASD #drugdevelopment

How are you today? Tell us what you want to hear from us. If you want to stay up-to-date with us, follow our Page. New Live Webinar with Q&A: "The Graphical Design Space for Primary Drying: Sources of Variability in the Dried Product Layer and Resistance and Impact on Cycle Design" Register Here: https://bit.ly/45eKlSo When: Thursday, August 24th, 10:00 AM ET Where: Your Laptop or Mobile Device Our Guest Speaker: Dr. Jayasree Srinivasan is a Research Scientist in the R&D laboratory at Baxter BioPharma Solutions in Bloomington, IN. Dr. Srinivasan’s expertise includes formulation (solution and lyophilized) and process development of sterile products. When not working on client projects, Jay conducts research in the lyophilization area and has contributed to numerous publications in reputed journals. She has developed and led curricula for lyophilization courses for professional advancement. Abstract: An emerging approach to lyophilization process development is to construct a graphical design space for primary drying as an aid to process optimization. The purpose of this investigation is to further challenge the assumption in earlier work that the resistance of dried product layer, Rp, is constant and is independent of process conditions within the design space. Three model formulations of BSA were prepared and a conservative lyophilization cycle was conducted for each formulation to collect mass flow data and individual design spaces was then established. A series of lyophilization cycles was then conducted using process conditions that resided within the individual design space and the resultant product temperatures and Rp values were compared. This presentation discusses the variability in the Rp of the formulations and the relationship between the sublimation rate and Rp. Webinar Highlights: - Is Rp the same within the design space of a formulation regardless of the process parameters used during primary drying? - How is Rp impacted by the formulation components? - How does Rp correlate with sublimation rate during primary drying? Register Here: https://bit.ly/45eKlSo

Discover the unbeatable combination of #value, #reliability, and #uninterrupted discovery with PURELAB Quest! 🧪💧 When it comes to #laboratory #water, compromise is not an option. That's why we've created a solution that consistently delivers three types of high-#quality water to support every application in your #lab. ⚗️ Need ultrapure water for sensitive experiments? 🔬 Require reliable pure water for analytical instruments? 🧫 Seeking high-quality general laboratory water? #PURELAB Quest has got you covered to exceed your expectations. With its cutting-edge technology and years of proven reliability, PURELAB Quest is the ultimate companion for #researchers and #scientists who strive for excellence. Ready to experience the difference? Choose PURELAB Quest and unlock a world of limitless possibilities in your lab. 💫🔬✨ ELGA LabWater PURELAB QUEST #watertreatment #purification #system #pharmaceutical #foodandbeverage #medicaldevices

Let’s define the future of lipid nanoparticles (#LNPs) as delivery systems for novel medicines together. Are you attending the LNP Formulation & Process Development Summit in 3 weeks? Tim Maguire, PhD & Aalok Shah be there and want to meet with you to discuss your LNP innovations! #nucleicacids #lnpsummit

Serán BioScience, a science driven CDMO, expands its early development capabilities with the addition of a pre-clinical small-scale custom spray dryer. This additional capability follows recent expansion of Serán's development facilities at the Bend, Oregon site. To facilitate formulation screening with discovery stage API, Serán’s new SD-5 for preclinical product development achieves high yields with batch sizes <50 mg of API. This new capability will enable rapid formulation screening of spray dried dispersions with minimal API. Read more here... https://hubs.li/Q02pFXJn0 Get started on your project: https://hubs.li/Q02pFS_J0 #drugdevelopment #drugformulation #cdmo #spraydrying

MediPhorum is currently developing a new collaboration that will address biocompatibility challenges related to the development of drug delivery combination products.   We are currently scoping out the key biocompatibility challenges that the combination products drug delivery industry is facing.   Biocompatibility is evolving rapidly with revisions to standards reflecting tighter regulations. There is a lot of confusion with the implementation of revised standards which can be interpreted differently resulting in a lack of clarity and confusion. Some of the challenges that have been highlighted include: - Estimating worst case exposure - The new introduction of cumulative effect (no standardized approach) - Differences in ISO vs USP standard requirements   If you are interested in participating in the collaboration or would like to share information about the challenges that you or your organization are facing on the topic of biocompatibility, please contact us: [email protected] #Biocompatibility #combinationproducts #drugdelivery #medtech

Exciting News!! We're thrilled to announce that Dr. Mothivel Mummudi-Boopathy, a Global Industry Leader from Tridiagonal Software Inc., will be presenting Poster-11 on the topic "Reduced Order Models (ROMs) – a Gateway to Geometry Aware Digital Twins” at PD2M Conference on #Modeling and #Simulation Applications in #Pharmaceutical Development and #Manufacturing. We will show how digital twins (DTs) for common pharma equipment like #agitatedvessels and #peristalticpumps can be generated using simulation data. In addition, we will discuss how these DTs can be used in business-critical applications. 📅 May 21st, 2024 ⌛ Between 18:15 - 19:30 EDT 📍  Cambridge, MA, US Please mark your calendars so that you don’t miss out on this great learning opportunity from the expert! Feel free to #connect post the session! 🚀 #PD2MConference #ModelingAndSimulation #DigitalTwins #PharmaceuticalDevelopment #ManufacturingSimulation