Did you know - Fibroblast Activation Protein-α (FAP) is a potential game-changer in #cancer therapy? Primarily expressed on tumor stroma cells, FAP represents a promising target across multiple cancer types which might be suitable for therapeutic radiopharmaceuticals. https://lnkd.in/ePh7Z6Zh #nuclearmedicine #radiopharma #oncology
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First-in-class bivalent functional degrader of the dark lipid kinase PIP4K2C for cancer. Efficacy and MoA demonstrated in ex vivo primary human patient colon cancer samples and in vivo in a colon cancer model. Learn more at the upcoming #AACR24.
Attending #AACR24? Larkspur’s Eva d'Hennezel will present new preclinical research on LRK-A, a first-in-class PIP4K2C protein degrader. The data demonstrate that LRK-A drives monotherapy anti-tumor activity, including complete tumor regressions, in primary human tumor samples and a mouse model of colorectal cancer. bit.ly/3VFTqCf #CancerResearch #Cancer #Oncology American Association for Cancer Research
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Researchers have discovered that a novel liquid biopsy test could play a crucial role in determining the most effective treatment for patients with non-small cell lung cancer (NSCLC) that has spread beyond the lungs. The study found that this liquid biopsy test, which identifies tumor DNA circulating in the blood, can help distinguish whether a patient's cancer has spread to just a few tumor sites or more widely. This discovery has significant implications for tailoring treatment approaches for NSCLC patients, optimizing their chances of successful outcomes. Read more: https://lnkd.in/d7zXWKVq #medical #oncology #lungcancer #dna #cancerresearch
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Researchers have discovered that a novel liquid biopsy test could play a crucial role in determining the most effective treatment for patients with non-small cell lung cancer (NSCLC) that has spread beyond the lungs. The study found that this liquid biopsy test, which identifies tumor DNA circulating in the blood, can help distinguish whether a patient's cancer has spread to just a few tumor sites or more widely. This discovery has significant implications for tailoring treatment approaches for NSCLC patients, optimizing their chances of successful outcomes. Read more: https://lnkd.in/d7zXWKVq #medical #oncology #lungcancer #dna #cancerresearch
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Desmoplastic small round cell tumor (DSRCT) is an aggressive pediatric #cancer with extremely poor prognosis due to its resistance to many treatment types. Using transcriptomic analysis of a novel cancer model, the lab of Tulane's Dr. Sean Lee has identified B-lymphocyte kinase as a potential drug target to reduce DSRCT chemotherapy resistance. #TulaneResearch #Oncology Read the paper in the comments! Image: Three different DSRCT cell lines (rows) at baseline or treated with different levels of two compounds known to inhibit B-lymphocyte kinase. Treatment decreased cancer cell viability, as quantified in bar graphs.
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NTRK fusions are a rare but relevant biomarker for cancer therapy decisions. The prevalence of NTRK fusions varies in different cancer entities and is, thus, of relevance for efficient patient screening. We recommend this interesting meta-analysis that provides the data for solid tumors. Read the review: https://lnkd.in/eaif4-Z6 Interested in more paper suggestions? Get our paper of the month delivered for free: https://lnkd.in/e9NqHK6C #cancer #targetedtherapy #pathology #precisionmedicine #biomarker #oncology #ntrk
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If you're attending AACR please swing by our poster presented by the eloquent Eva d'Hennezel and learn more about our first-in-class PIP4K2C degrader!
Attending #AACR24? Larkspur’s Eva d'Hennezel will present new preclinical research on LRK-A, a first-in-class PIP4K2C protein degrader. The data demonstrate that LRK-A drives monotherapy anti-tumor activity, including complete tumor regressions, in primary human tumor samples and a mouse model of colorectal cancer. bit.ly/3VFTqCf #CancerResearch #Cancer #Oncology American Association for Cancer Research
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For patients who present with advanced stage cervical cancer, targeted therapies can improve outcomes. Join us for a molecular tumor board as we discuss treatment options for patients with recurrent cervical cancer and how biomarker-directed therapies are transforming the standard of care. #MolecularTumorBoard #PrecisionOncology #cervicalcancer #cancer #tumormicroenvironment #oncology #biomarkers
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Today is World Lung Cancer Day. At SOTIO, we are advancing differentiated and novel antibody-drug conjugates with the potential to treat #lungcancer and other solid tumors. #biotechnology #oncology #cancer #research #ADC #jsmePPF
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Recognizing and mitigating cancer treatment toxicities is an essential piece of a survivorship plan after curing #cancer. Our latest molecular tumor board discusses an important intersection of cardiology and oncology in breast cancer through a case of a 33-year-old female with locally advanced ER/PR-negative, HER2-positive breast cancer. We reviewed side effect profiles of anthracyclines and anti-HER2 monoclonal antibodies along with recent updated recommendations from the European Society of Cardiology on cardiovascular surveillance and risk assessment in long-term follow-up after discontinuation of cancer treatment. #NationalCancerPreventionMonth #breastcancer #adverseevents #oncology #precisiononcology
Molecular Tumor Board: 33 year-old female with locally advanced ER/PR-negative, HER2-positive breast cancer
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Can you simultaneously analyze 500+ genes with known cancer associations across 28+ solid tumor types in a single assay? Yes, you can! The table below gives you an overview of the tumor types we cover with our Comprehensive Cancer Panel solution. To learn more about the workflow and advantages of this solution, visit https://lnkd.in/eibcCs7c #genomescan #cancer #oncology #cancerresearch #biomarkers #tumor #ngs #sequencing Stefanie Klaver-Flores, PhD
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