American Society of Clinical Oncology (ASCO)- Society of Surgical Oncology Guidelines (2024) suggests Universal Germline testing for all patients with #breastcancer <65 years and suggests broader testing beyond BRCA1 / BRCA2 to include high penetrance genes
Read the full guideline at https://lnkd.in/g8sS-F8d
Highlights
All patients newly diagnosed with breast cancer who are 65 years or younger at diagnosis should be offered BRCA1/2 testing
All patients newly diagnosed with breast cancer who are older than age 65 should be offered BRCA1/2 testing if:
they are candidates for PARPi
they have TNBC
personal or family history
they were assigned male sex at birth,
they are of Ashkenazi Jewish ancestry / or are members of a population with an increased prevalence of founder mutations
All patients with recurrent breast cancer (local or metastatic) who are candidates for PARP inhibitor therapy should be offered BRCA1/2 testing regardless of family history
All patients with a personal history of breast cancer diagnosed ≤65 years who are without active disease should be offered BRCA1/2 testing if the result will inform personal risk management or family risk assessment
#GenePanel
Testing for high penetrance genes beyond BRCA1/2, including PALB2, TP53, PTEN, STK11, and CDH1, could inform medical therapy, influence surgical decision making, refine estimates of risks of second primary cancer, and inform family risk assessment, and thus should be offered to appropriate patients
#GeneticCounselling
Patients undergoing genetic testing should be given sufficient information before testing to provide informed consent
#genomics #publichealth #cancer #Genomics4Everyone
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