Sr. Scientist/Principal Scientist– Protein Sciences

Sr. Scientist/Principal Scientist– Protein Biochemist

A stealth mode Third Rock Ventures start up is seeking a dynamic and motivated Biochemist/Biophysicist with significant experience in Drug Discovery to become an integral part of the Discovery Biologics group. The successful candidate will spearhead the development and execution of a diverse range of biochemical and biophysical assays, crucial in advancing the company’s Discovery pipeline. We are looking for an individual with outstanding communication and collaboration abilities, who excels in cross-functional, multi-disciplinary drug discovery teams. Additionally, experience in managing direct reports and coordinating with external CROs is highly valued.

Key Responsibilities:

· Contribute to the overall scientific strategy and build out of the Discovery Biologics group

· Design and execute a wide range of biochemical and biophysical assays for screening and characterizing protein-protein and protein-ligand interactions

· Conduct stability and developability studies on biologics to inform lead candidate selection

· Utilize structural, sequence, and computational tools to design protein constructs

· Skillfully label and characterize protein reagents using biotin/fluorophores

· Oversee external research at CROs, managing activities, assay development, and facilitating seamless data and reagent transfers internally

· Proactively assess and integrate new screening technologies into the drug discovery process

· Proficiently express and purify antibodies and novel biologics utilizing standard techniques

· Develop and execute project plans, coordinating workflows and logistics to achieve project milestones

· Effectively present research findings at internal meetings and external scientific conferences

Candidate Requirements:

· Ph.D. in Biochemistry, Biophysics, Structural Biology, or related field or B.Sc./M.Sc. with 2+ years of relevant experience in the Biotech Industry.

· Essential expertise in SPR (BIAcore) and proficiency in utilizing other biophysical techniques (BLI, ITC, FP, DLS) for characterizing protein-protein interactions

· Proficiency in structural biology and computational tools to aid in designing of protein constructs

· Strong grasp of biochemical methods for protein purification, including affinity, IEX, SEC, HIC, and MMC

· Embraces new challenges and thrives in a dynamic, start-up environment

· Demonstrates a strong work ethic and high motivation

· Capable of working both independently and collaboratively within a team to meet deadlines and contribute to strategic company objectives

· Excellent written and verbal communication skills