Senior Computational Scientist

Location: Cambridge, MA

Flagship Labs 104 (FL104) is a privately held, early-stage company leveraging artificial intelligence and large language models (LLMs) to transform how we reason about complex phenomena. This is a unique opportunity to be at the forefront of scientific innovation, as we leverage cutting-edge advancements in AI and ML to drive breakthroughs in drug discovery and fundamental science.

About Flagship

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Position Summary:

We are seeking a motivated and experienced Senior Computational Scientist to join our innovative team at Flagship Labs 104 (FL104). In this pivotal role, you will have the opportunity to apply your expertise in computational biology to develop novel methodologies and algorithms, furthering our understanding of complex biological systems. As part of our mission-driven team, you'll contribute your quantitative and computational skills to revolutionize our approach towards drug discovery, leveraging cutting-edge advancements in AI and ML. This role offers the opportunity to significantly influence our scientific and technical trajectory, working in a dynamic, early-stage environment.

Key Responsibilities:

• Develop and validate preclinical PK/PD models, agent-based models, and ODEs or other similar statistical models to elucidate quantitative biological relationships.
• Identify opportunities where model-informed drug development can advance the understanding of biology, pharmacological activity, and safety.
• Contribute to a cooperative software development environment through Git usage, engagement in code reviews, and individual development of reliable code.
• Containerize applications using Docker and manage CI/CD pipelines for streamlined development.
  
  

Qualifications:

• Ph.D. in computational biology, statistics, bioinformatics, or a related field.
• 5+ years of experience applying quantitative approaches to solve biological problems.
• Proficiency in programming with Python and working with cloud platforms (AWS preferred).
• Energetic self-starter with the ability to work effectively in a startup environment.
• Exemplary analytical skills and ability to synthesize & communicate complex information rapidly and effectively.
  
  

Preferred Qualifications:

• Solid experience with deep learning, particularly with LLMs.
• Strong background in research methodologies related to systems biology, and PK/PD, agent-based models, or similar modeling approaches.
• Experience working in the pharmaceutical or biotech industry.
• Experience with workflow orchestration and containerization.
• Experience working with CI/CD pipelines.
  
  

Why Join Us?

FL104 offers you a unique opportunity to:

• Collaborate with highly talented, interdisciplinary team members.
• Participate in the evolution of a pioneering early-stage company, with the immense potential to transform how much a single scientist can accomplish.
• Contribute to a proactive work culture, with an emphasis on mutual learning and continuous improvement.
  
  

Values and Behaviors:

Flagship is an experiment in institutional, entrepreneurial, and innovation practiced in the context of a small company with an insurgent mindset. We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment. The level of the role will be commensurate with the education and years of experience of the identified candidates.

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.