Scientist I/II

Company Information

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell and natural killer (NK) cell-based immunotherapy.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel) in 2017. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking Scientist I/II as part of the R&D Novel CAR Design team based in Piscataway, NJ.

Role Overview

To substantially improve function (efficacy and safety profiles) and fitness of immune cellbased modalities, which helps overcome shortcomings of engineered immune cells in clinics, the R & ED team is willing to seek a highly motivated scientist to investigate novel cytokine arming strategies and identify optimal ones. The candidate will coordinate with other team members to timely perform research activities, analyze data and report results along with other lab duties. The ideal candidate has experience in immune-oncology and/or CAR natural killer (NK) and/or gamma-delta (gd) T cells and is willing to embrace new challenges and technologies. The candidate in this role will have exposure to up-to-date knowledge and techniques in cell-based cancer immunotherapy.

Key Responsibilities

• Execute experiments designed to characterize the function and fitness of immune cell therapy candidates.
• Strong wet-lab experience including virus preparation/transduction, CAR NK and/or gd T activation and phenotypic tumor killing assay, multi-color flow cytometry.
• Develop/optimize functional assays to screen and identify potential candidates.
• Keep accurate laboratory documentation, especially electronic lab notebook.
• Maintain GxP and EHS compliance.
• Analyze and report scientific data in a timely manner.
• Present results in small team and large functional group meetings.
  
  
  

Requirements

• PhD’s degree in immunology, tumor biology or a relevant biological field.
• 3+ year of experience in cancer immunotherapy, cell therapy, immunology or oncology, and/or CAR NK/gd T cells.
• Experience of immune cell isolation, activation/expansion from human PBMCs.
• Experience in lentivirus and/or retrovirus production and transduction is required.
• Extensive experience in cellular and immune cell-based analytics and assay development, including but not limited to, advanced multi-parameter flow-cytometry, cell labeling, mixed lymphocyte reactions, cell proliferation assays, cytotoxicity assays, cytokine release ELISA/MSD multiplex assays is highly required.
• Critical thinker with strong problem-solving skills.
• Up-to date knowledge of immunology and immunotherapy.
• Track record of productivity evidenced by publications or patents.
• Independently plan and timely execution of research programs.
• Excellent oral and written communication skills.
• A team player who can work efficiently as an individual.
  
  
  

Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

Legend Biotech maintains a drug-free workplace.

Benefits:

• Health Insurance
• Dental Insurance
• Vision Insurance
• Life Insurance
• Matched 401K
• Flexible Spending Account
• Health Savings Account
• AD&D Insurance
• Short-Term Disability
• Long-Term Disability
• Paid Maternity Leave
• Paid Paternity Leave
• Pet Insurance
• Critical Illness Insurance
• Hospital Indemnity Insurance
• Accident Insurance
• Legal Insurance
• Commuter Benefits
• Employee Assistance Program