Scientist, Analytical Development

We are a dedicated group of scientists, physicians, and businesspeople working together toward one goal: to discover and develop therapies that can unleash the power of the body’s immune system to treat and potentially cure cancer. We are passionate about the work we do every day at Agenus to deliver on the promise of immuno-oncology. If you’re looking for an inspired environment, passionate colleagues, and a culture that nurtures learning, innovation and team success, we invite you to join us.

The Role

We are seeking a Scientistto join our team to contribute to the development of new analytical methodologies and optimize existing methods; to establish robust assays that can be used to characterize different novel therapeutic drugs (monoclonal antibodies, bispecific antibodies, fusion proteins, etc.) from early-stage clinical development through late-stage/commercialization and product lifecycle management. In this role, you will be responsible for timely development of analytical methods supporting process development and qualification of methods for Quality Control for release and stability testing in compliance with Agenus Quality Systems. In addition, you will be supporting IND enabling biochemical and biophysical characterization to understand the structure and function of our molecules and the processes we use to purify them. You will be asked to ensure the appropriate and timely progression of methods development for preclinical development and early-phase clinical product cGMP manufacture.

In The Role You Will

Perform routine and novel testing to support biological therapeutic products from early-stage development through late-stage/commercialization and their lifecycle management.

Analytical methods may include, but not limited to: SE-HPLC, CEX-HPLC, HILIC-HPLC, reduced and nonreduced CE-SDS, cIEF, concentration by A280, and ELISA assays

Support product testing for upstream and downstream process development and cell engineering teams

Author and summarize test data in accurate, technical reports.

Perform data analysis and troubleshooting of analytical methods as needed.

Write, review, and edit SOPs and Test Methods for new procedures and assays; review, edit and revise existing SOPs to reflect changes in procedures.

Write technical development reports and give oral presentations of data at departmental or interdepartmental meetings

Coordinate with other functional groups to support upstream and downstream process development studies and have some understanding and experience with determining critical quality attributes of protein products

Maintain lab compliance by performing routine housekeeping, including support of analytical instrument maintenance, ordering and stocking of lab supplies, maintaining of reagents, sample management, and compliance to safety regulations

Teamwork and communication are key attributes needed for this position, as this role will be part of a small team. A collaborative attitude and a positive work ethic are key traits for success.

Qualifications: About You

Master’s or Bachelor’s degree in a Scientific field (e.g., Chemistry, Biochemistry, Biology or similar field) with at least 3+ years of relevant experience in a biologic product development or QC environment. Or PhD with relevant experience/knowledge.

Excellent observation and attention to detail and accuracy for record keeping and documentation

Excellent verbal and written communications skills

Ability to work independently, and as part of a team

Proficiency with Microsoft Word, Excel and PowerPoint software is required.

Experience troubleshooting and developing CE-SDS or iCIEF methods.

Experience in analytical method troubleshooting, optimization, and validation.

Experience with LC-MS is a plus

Ability to provide scientific input and demonstrate critical thinking for experimental design and execution.

The targeted salary range for this position is 95,000-120,000 per year. Agenus is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offered is commensurate with Agenus’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, critical needs of the role, and internal equity.

Read more about our pipeline and visit us on LinkedIn

Agenus is Delighted to Provide you With a Comprehensive Benefits Plan, Including Some of the Following:

• Highly competitive and inclusive medical, dental and vision coverage options (US & UK)
• Flexible Spending Accounts for medical expenses and dependent care expenses (US)
• Flexible Vacation Plan (US & UK)-In a time when we move at the speed of light, what matters most is what we achieve, not how many hours we clock or accrue. We want people to take breaks when they need them most and own their time. Our philosophy at Agenus is that freedom to take this time will lead to clarity, creativity and innovation through rested and refreshed eyes. With our Flexible Vacation Plan, Agenus will not limit the amount of vacation you can take. It will allow you to take the vacation time as you need, while fulfilling your job responsibilities and making meaningful contributions to our mission.
• Care.com Memberships (US)
• Education Assistance Program (US & UK)
• 401k match (US) and Financial Planning tools, Private Pension (UK)
• Employee Stock Purchase Plans (US &UK)
• Employee Assistance Program (US &UK)
• Reward & Recognition Program (US & UK)
• Catered Lunch (site dependent)
• Onsite Yoga (UK)
• Free Parking (US & UK)
  
  

Our core values

The way we work sets Agenus apart.

We put the patient first.

We aspire to change the world, improving the experience and options available for every single cancer patient. The answers are out there, and patients are waiting.

We are bold, and we are one.

We believe that the only way to deliver on our goals is to aim high and work as one global team. We look for opportunities to challenge, collaborate with, and support one another. We aim to break conventional standards and perform at extraordinary levels.

We work with integrity, respect and honesty.

These three building blocks serve as pillars for how we behave, operate, and execute our mission.

We are a culture of ownership and accountability.

We hold ourselves accountable not only for exceptional results, but how we get our results.

We are obsessively curious and deeply committed to learning.

We live in a fast-paced environment that requires us to learn at or above the speed of change. We believe that curiosity fuels the desire to create, and learning provides the tools to progress.

We perform at our best every day.

Every day counts. We confront insurmountable obstacles, problems and choices with intellect, perseverance and hard work.