Maze Therapeutics

We are proud to announce that we have completed an exclusive worldwide license agreement with Shionogi & Co., Ltd for the rights to MZE001. MZE001 is a small molecule inhibitor of GYS1, an enzyme involved in glycogen synthesis, that is designed to reduce glycogen concentration in muscles. The results from the Phase 1 study of MZE001 suggest that it has the potential to be the first oral therapy for the treatment of #Pompedisease, a congenital metabolic #raredisease. Shionogi has an impressive track record of developing and delivering innovative treatments for patients, and we are confident in their commitment to the advancement of this asset. Read the full announcement here: https://lnkd.in/euv979a8

Today marks the very first annual APOL1-Mediated Kidney Disease (AMKD) Awareness Day. APOL1-mediated kidney disease is a genetic condition that can cause kidney failure, and disproportionately affects people of Western and Central African descent. We're raising awareness alongside the American Kidney Fund for those living with APOL-1 #kidneydisease. At Maze, we're developing MZE829, a potential oral medicine that is currently in Phase 1 clinical trials. We invite you to learn more and raise awareness about AMKD and promote being #APOL1aware. By working together as a community, we can expand our understanding of APOL1's association with kidney disease. Join us in making a difference here: https://lnkd.in/eBbath4Z 

We recently hosted a Botanicals and Brews celebration in honor of #EarthDay2024. Thanks to Mazers Terrence Satterfield and Vinita Shah B. for leading an engaging workshop which included growing plants without soil, better known as hydroponic gardens, a hobby that blends science with #sustainability to promote environmentally friendly food production. We enjoyed celebrating our planet while making memories together!

Today, we honor #InternationalPompeDay alongside those within the #PompeDisease community. Please join us as we celebrate this group of resilient and dedicated individuals. #TogetherWeAreStrong

We recently had the privilege of hosting Cynthia Burks as a guest speaker, and her insights on personal and professional growth were truly invaluable. She brought to the table a wealth of experience, from her journey as an independent business owner to her roles in HR, ultimately rising to the position of chief human resources officer. Her diverse background provided our team with a fresh perspective on navigating one’s career and seizing opportunities for growth. We're incredibly grateful for her time and the knowledge she shared with us!

In honor of #WomensHistoryMonth, Maze's DEI council hosted a panel discussion featuring four Mazers who shared their inspiring career journeys and emphasized the significance of everyday acts of inclusion. A huge thank you to our panelists: Susan Limb, Sarah Bronner, Madhuri Sudharshan Gota, and Tracy Yenshaw. Your insights and experiences have left a lasting impact on all who tuned in for the event. 

An estimated 37 million people are living with chronic #kidneydisease. As #NationalKidneyMonth wraps up, we hope that you will learn more about this pervasive disease and how you can make a difference for patients. At Maze, we are proud to be a part of the efforts to continue development for potential medicines and support the National Kidney Foundation and their ongoing efforts.

APOL1 #kidneydisease is a life threatening, genetically driven condition that is estimated to impact close to one million people of West African ancestry in the U.S. alone. #APOL1 kidney disease leads to kidney damage that may be discovered on laboratory tests and/or cause signs and symptoms that may disrupt a patient's everyday life. During #NationalKidneyMonth, we're pleased to come together with the kidney disease community to raise awareness of the challenges patients face and the need for new treatments. Take a look below, and read about our efforts to help make a difference for patients here: https://lnkd.in/e9scsmG6 

March is #WomensHistoryMonth, and we're proud to stand behind initiatives that empower and uplift women in science, leadership, and beyond. Check back here for more on how Maze is honoring the occasion this month.

We recently hosted guest speaker Michael Caplan of Yale University at our Maze HQ to give a rundown on new signaling pathways and therapeutic targets for polycystic #kidneydisease. We enjoyed learning from him, as Michael's work focuses specifically on understanding the ways in which #kidney cells organize and maintain their unique structures. We're inspired by the continuous progress being made in the kidney disease space. #NationalKidneyMonth