The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

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Biowulf Utilization
Sunday, June 2nd, 2024
utilization graph
Last 24 hrs
44,821 jobs submitted
33,068 jobs completed
2,412,892 CPU hrs used
20 NIH Institutes
198 Principal Investigators
375 users

Announcements
Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper An acetyltranferase moonlights as a regulator of the RNA binding repertoire of the RNA chaperone Hfq in Escherichia coli
Luo, X; Zhang, A; Tai, CH et al.
Proc Natl Acad Sci U S A , DOI://10.1073/pnas.2311509120 (2023)


thumbnail image from paper Microbiota configuration determines nutritional immune optimization
Han, SJ; Stacy, A; Corral, D et al.
Proc Natl Acad Sci U S A , DOI://10.1073/pnas.2304905120 (2023)


thumbnail image from paper The reference genome of Macropodus opercularis (the paradise fish)
Fodor, E; Okendo, J; Szabó, N et al.
Sci Data , DOI://10.1038/s41597-024-03277-1 (2024)


thumbnail image from paper Profiling complex repeat expansions in RFC1 in Parkinson's disease
Alvarez Jerez, P; Daida, K; Miano-Burkhardt, A et al.
NPJ Parkinsons Dis , DOI://10.1038/s41531-024-00723-0 (2024)


thumbnail image from paper UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency
Chapman, JH; Youle, AM; Grimme, AL et al.
Nucleic Acids Res , DOI://10.1093/nar/gkae136 (2024)


thumbnail image from paper Examining chromatin heterogeneity through PacBio long-read sequencing of M.EcoGII methylated genomes: an m6A detection efficiency and calling bias correcting pipeline
Dennis, AF; Xu, Z; Clark, DJ; ,
Nucleic Acids Res , DOI://10.1093/nar/gkae288 (2024)


thumbnail image from paper Genome-wide analyses reveals an association between invasive urothelial carcinoma in the Shetland sheepdog and NIPAL1
Parker, HG; Harris, AC; Plassais, J et al.
NPJ Precis Oncol , DOI://10.1038/s41698-024-00591-0 (2024)


thumbnail image from paper Germline pathogenic variants associated with triple-negative breast cancer in US Hispanic and Guatemalan women using hospital and community-based recruitment strategies
Godinez Paredes, JM; Rodriguez, I; Ren, M et al.
Breast Cancer Res Treat , DOI://10.1007/s10549-024-07300-2 (2024)