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Page 1
Peripherin is a biomarker of axonal damage in peripheral nervous system disease.
Keddie S, Smyth D, Keh RYS, Chou MKL, Grant D, Surana S, Heslegrave A, Zetterberg H, Wieske L, Michael M, Eftimov F, Bellanti R, Rinaldi S, Hart MS, Petzold A, Lunn MP. Keddie S, et al. Brain. 2023 Nov 2;146(11):4562-4573. doi: 10.1093/brain/awad234. Brain. 2023. PMID: 37435933 Free PMC article.
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators. Salloway S, et al. N Engl J Med. 2014 Jan 23;370(4):322-33. doi: 10.1056/NEJMoa1304839. N Engl J Med. 2014. PMID: 24450891 Free PMC article. Clinical Trial.
BACKGROUND: Bapineuzumab, a humanized anti-amyloid-beta monoclonal antibody, is in clinical development for the treatment of Alzheimer's disease. METHODS: We conducted two double-blind, randomized, placebo-controlled, phase 3 trials involving patients with mild-to-moderate …
BACKGROUND: Bapineuzumab, a humanized anti-amyloid-beta monoclonal antibody, is in clinical development for the treatment of Alzheimer's …
Immunoglobulin for multifocal motor neuropathy.
Keddie S, Eftimov F, van den Berg LH, Brassington R, de Haan RJ, van Schaik IN. Keddie S, et al. Cochrane Database Syst Rev. 2022 Jan 11;1(1):CD004429. doi: 10.1002/14651858.CD004429.pub3. Cochrane Database Syst Rev. 2022. PMID: 35015296 Free PMC article. Review.
Prenatal iron deficiency causes sex-dependent mitochondrial dysfunction and oxidative stress in fetal rat kidneys and liver.
Woodman AG, Mah R, Keddie D, Noble RMN, Panahi S, Gragasin FS, Lemieux H, Bourque SL. Woodman AG, et al. FASEB J. 2018 Jun;32(6):3254-3263. doi: 10.1096/fj.201701080R. Epub 2018 Jan 19. FASEB J. 2018. PMID: 29401611
These findings indicate that prenatal iron deficiency causes changes in mitochondrial content and function as well as oxidant status in a sex- and organ-dependent manner, which may be an important mechanism that underlies the programming of cardiovascular disease.-Woodman, A. G., …
These findings indicate that prenatal iron deficiency causes changes in mitochondrial content and function as well as oxidant status in a se …
Stereochemical outcomes of C-F activation reactions of benzyl fluoride.
Keddie NS, Champagne PA, Desroches J, Paquin JF, O'Hagan D. Keddie NS, et al. Beilstein J Org Chem. 2018 Jan 9;14:106-113. doi: 10.3762/bjoc.14.6. eCollection 2018. Beilstein J Org Chem. 2018. PMID: 29441134 Free PMC article.
In recent years, the highly polar C-F bond has been utilised in activation chemistry despite its low reactivity to traditional nucleophiles, when compared to other C-X halogen bonds. Paquin's group has reported extensive studies on the C-F activation of benzylic fluorides …
In recent years, the highly polar C-F bond has been utilised in activation chemistry despite its low reactivity to traditional nucleophiles, …
Molecular recognition of fluorine impacts substrate selectivity in the fluoroacetyl-CoA thioesterase FlK.
Weeks AM, Keddie NS, Wadoux RD, O'Hagan D, Chang MC. Weeks AM, et al. Biochemistry. 2014 Apr 1;53(12):2053-63. doi: 10.1021/bi4015049. Epub 2014 Mar 17. Biochemistry. 2014. PMID: 24635371 Free PMC article.
Using a combination of pH-rate profiles, pre-steady-state kinetic experiments, and Taft analysis of wild-type and mutant FlKs with a set of substrate analogues, we explore the role of fluorine in controlling the enzyme acylation and deacylation steps. Further analysis of chiral ( …
Using a combination of pH-rate profiles, pre-steady-state kinetic experiments, and Taft analysis of wild-type and mutant FlKs with a set of …
26 results