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14 results

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Page 1
Fatty acid transport protein 2 reprograms neutrophils in cancer.
Veglia F, Tyurin VA, Blasi M, De Leo A, Kossenkov AV, Donthireddy L, To TKJ, Schug Z, Basu S, Wang F, Ricciotti E, DiRusso C, Murphy ME, Vonderheide RH, Lieberman PM, Mulligan C, Nam B, Hockstein N, Masters G, Guarino M, Lin C, Nefedova Y, Black P, Kagan VE, Gabrilovich DI. Veglia F, et al. Nature. 2019 May;569(7754):73-78. doi: 10.1038/s41586-019-1118-2. Epub 2019 Apr 17. Nature. 2019. PMID: 30996346 Free PMC article.
The main mechanism of FATP2-mediated suppressive activity involved the uptake of arachidonic acid and the synthesis of prostaglandin E(2). The selective pharmacological inhibition of FATP2 abrogated the activity of PMN-MDSCs and substantially delayed tumour progression. .. …
The main mechanism of FATP2-mediated suppressive activity involved the uptake of arachidonic acid and the synthesis of prostaglandin E …
Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy.
Tcyganov EN, Sanseviero E, Marvel D, Beer T, Tang HY, Hembach P, Speicher DW, Zhang Q, Donthireddy LR, Mostafa A, Tsyganova S, Pisarev V, Laufer T, Ignatov D, Ferrone S, Meyer C, Maby-El Hajjami H, Speiser DE, Altiok S, Antonia S, Xu X, Xu W, Zheng C, Schuchter LM, Amaravadi RK, Mitchell TC, Karakousis GC, Yuan Z, Montaner LJ, Celis E, Gabrilovich DI. Tcyganov EN, et al. Cancer Cell. 2022 Oct 10;40(10):1173-1189.e6. doi: 10.1016/j.ccell.2022.09.001. Cancer Cell. 2022. PMID: 36220073 Free PMC article.
Vascular endothelial growth factor impairs the functional ability of dendritic cells through Id pathways.
Laxmanan S, Robertson SW, Wang E, Lau JS, Briscoe DM, Mukhopadhyay D. Laxmanan S, et al. Biochem Biophys Res Commun. 2005 Aug 19;334(1):193-198. doi: 10.1016/j.bbrc.2005.06.065. Biochem Biophys Res Commun. 2005. PMID: 16002046 Free PMC article.
VEGF appears to diminish host immunity by altering the function of major antigen-presenting cells such as dendritic cells (DCs) [D.I. Gabrilovich, T. Ishida, S. Nadaf, J.E. Ohm, D.P. Carbone, Antibodies to vascular endothelial growth factor enhance the efficacy of c …
VEGF appears to diminish host immunity by altering the function of major antigen-presenting cells such as dendritic cells (DCs) [D.I. Gab …
International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis.
Chen X, Tsvetkov AS, Shen HM, Isidoro C, Ktistakis NT, Linkermann A, Koopman WJH, Simon HU, Galluzzi L, Luo S, Xu D, Gu W, Peulen O, Cai Q, Rubinsztein DC, Chi JT, Zhang DD, Li C, Toyokuni S, Liu J, Roh JL, Dai E, Juhasz G, Liu W, Zhang J, Yang M, Liu J, Zhu LQ, Zou W, Piacentini M, Ding WX, Yue Z, Xie Y, Petersen M, Gewirtz DA, Mandell MA, Chu CT, Sinha D, Eftekharpour E, Zhivotovsky B, Besteiro S, Gabrilovich DI, Kim DH, Kagan VE, Bayir H, Chen GC, Ayton S, Lünemann JD, Komatsu M, Krautwald S, Loos B, Baehrecke EH, Wang J, Lane JD, Sadoshima J, Yang WS, Gao M, Münz C, Thumm M, Kampmann M, Yu D, Lipinski MM, Jones JW, Jiang X, Zeh HJ, Kang R, Klionsky DJ, Kroemer G, Tang D. Chen X, et al. Autophagy. 2024 Mar 24:1-34. doi: 10.1080/15548627.2024.2319901. Online ahead of print. Autophagy. 2024. PMID: 38442890 Free article. Review.
Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through the selective degradation of anti-injury proteins or organelles. Conversely, other f …
Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in …
Identifying COVID-19 Vaccine Deserts and Ways to Reduce Them: A Digital Tool to Support Public Health Decision-Making.
Weintraub RL, Miller K, Rader B, Rosenberg J, Srinath S, Woodbury SR, Schultheiss MD, Kansal M, Vispute S, Serghiou S, Flores G, Kumok A, Shekel T, Gabrilovich E, Ahmad I, Chiang ME, Brownstein JS. Weintraub RL, et al. Am J Public Health. 2023 Apr;113(4):363-367. doi: 10.2105/AJPH.2022.307198. Epub 2023 Feb 2. Am J Public Health. 2023. PMID: 36730873 Free PMC article.
Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway.
Alicea-Torres K, Sanseviero E, Gui J, Chen J, Veglia F, Yu Q, Donthireddy L, Kossenkov A, Lin C, Fu S, Mulligan C, Nam B, Masters G, Denstman F, Bennett J, Hockstein N, Rynda-Apple A, Nefedova Y, Fuchs SY, Gabrilovich DI. Alicea-Torres K, et al. Nat Commun. 2021 Mar 19;12(1):1717. doi: 10.1038/s41467-021-22033-2. Nat Commun. 2021. PMID: 33741967 Free PMC article.
Revealed versus potential spatial accessibility of healthcare and changing patterns during the COVID-19 pandemic.
Gligorić K, Kamath C, Weiss DJ, Bavadekar S, Liu Y, Shekel T, Schulman K, Gabrilovich E. Gligorić K, et al. Commun Med (Lond). 2023 Nov 3;3(1):157. doi: 10.1038/s43856-023-00384-9. Commun Med (Lond). 2023. PMID: 37923904 Free PMC article.
In conjunction with other relevant data, these findings provide a resource to help public health policymakers identify underserved populations and promote health equity by formulating policies and directing resources towards areas and populations most in need. Spatial access to h …
In conjunction with other relevant data, these findings provide a resource to help public health policymakers identify underserved populatio …
Multisite Clinical Validation of Isothermal Amplification-Based SARS-CoV-2 Detection Assays Using Different Sampling Strategies.
Desai KT, Alfaro K, Mendoza L, Faron M, Mesich B, Maza M, Dominguez R, Valenzuela A, Acosta CD, Martínez M, Felix JC, Masch R, Smith JS, Gabrilovich S, Wu T, Plump M, Novetsky AP, Einstein MH, Douglas NC, Cremer M, Wentzensen N. Desai KT, et al. Microbiol Spectr. 2021 Oct 31;9(2):e0084621. doi: 10.1128/Spectrum.00846-21. Epub 2021 Oct 20. Microbiol Spectr. 2021. PMID: 34668736 Free PMC article.
., UK), compared with those of clinical RT-PCR tests using different sampling strategies (i.e., nasopharyngeal, self-sampled anterior nares, self-sampled midturbinate, and saliva). ...
., UK), compared with those of clinical RT-PCR tests using different sampling strategies (i.e., nasopharyngeal, self-sampled anterior …
14 results